Immunotherapy and Vaccine Development
نویسندگان
چکیده
منابع مشابه
Hepatitis C Virus and Vaccine Development
The prevalence of Hepatitis C virus (HCV) is approximately 3% around the world. This virus causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The effectiveness of interferon-α and ribavirin therapy is about 50% and is associated with significant toxicity and cost. Hence, generating new vaccines or drugs is an obligation. However, there is no vaccine available for clinical u...
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DNA vaccination has emerged as an attractive immunotherapeutic approach against cancer due to its simplicity, stability, and safety. Results from numerous clinical trials have demonstrated that DNA vaccines are well tolerated by patients and do not trigger major adverse effects. DNA vaccines are also very cost effective and can be administered repeatedly for long-term protection. Despite all th...
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Accumulating evidence shows that tumours contain a distinct subpopulation of cancer stem cells (CSCs) which are capable of self-renewal, differentiation, and tumour-initiation[1,2]. Previous studies have demonstrated that cancer stem cells are relatively resistant to chemoand radio-therapies[3,4], and play an essential role in tumour recurrence and metastasis. Since multiple human malignancies ...
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Despite the tremendous potential of peptide-based cancer vaccines, their efficacy has been limited in humans. Recent innovations in tumour exome sequencing have signalled the new era of personalized immunotherapy with patient-specific neoantigens, but a general methodology for stimulating strong CD8α+ cytotoxic T-lymphocyte (CTL) responses remains lacking. Here we demonstrate that high-density ...
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Note: The author of this paper is not an M.D. The contents of this paper are based on the listed references and are offered for educational and informational purposes only. This article is meant to bring attention to a timely treatment therapy concept that should be considered; it is not meant to be a complete literature review for either immunotherapy or vaccine therapy. Patients should refer ...
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ژورنال
عنوان ژورنال: Journal of Immunology Research
سال: 2018
ISSN: 2314-8861,2314-7156
DOI: 10.1155/2018/8751027